LL-37
Preclinicalaka Cathelicidin, CAP-18 fragment
Your body's own antibiotic. A broad antimicrobial and immune-signalling peptide.
Mechanism
The active fragment of human cathelicidin, a host-defense peptide that kills microbes directly and also runs inflammation, wound healing, and immune signalling. Double-edged though: too much of it is implicated in some inflammatory skin conditions.
Regulatory & Safety Status
Research stage, not approved as a therapeutic. Mostly a lab compound for now.
Research
Chicken cathelicidin-3 protected mice from avian pathogenic Escherichia coli infection mediated by triggering chemokine CCL3 pathway
Impact of cathelicidin cleavage by SpeB on Streptococcus pyogenes CovRS signaling
Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling
Membrane Disruption and Charge Neutralization Drive Synergy Between LL37-Derived Peptides and Polymyxins Against E. coli
Latest LL-37 research