SS-31
Phase 3aka Elamipretide, MTP-131
Mitochondria-targeting peptide in phase 3 for rare mitochondrial disease.
Mechanism
A tetrapeptide that binds cardiolipin in the inner mitochondrial membrane, basically trying to fix the wiring so the mitochondria make energy properly again. One of the few here in serious late-stage trials.
Regulatory & Safety Status
Investigational (Stealth BioTherapeutics), late-stage trials for rare mitochondrial conditions. Not approved.
Research
Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging
Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework
The Oxidative-Mitochondrial-Inflammatory Axis in Retinitis Pigmentosa: Extracellular mtDNA as Biomarker and Therapeutic Read-Out
SS31 protects damaged retinal cells through the AMPK/DRP1 signaling pathway
Latest elamipretide research