MOTS-c
Preclinicalaka Mitochondrial ORF of the 12S rRNA type-c
Mitochondrial peptide that acts like an exercise mimetic, at least in mice. A longevity-crowd favourite.
Mechanism
Coded inside your mitochondrial DNA. It seems to manage metabolism and insulin sensitivity, and in animals it does a lot of what exercise does. Promising, but the human work is barely started.
Regulatory & Safety Status
Early research, not approved, and the human data is very limited. Treat the longevity claims as hopeful, not proven.
Research
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities
Emerging regulators of human physiology and disease; sORF-encoded microproteins
Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy
MOTS-c metabolism and aging research
Latest MOTS-c research