MOTS-c
Preclinicalaka Mitochondrial ORF of the 12S rRNA type-c
Mitochondrial peptide that acts like an exercise mimetic, at least in mice. A longevity-crowd favourite.
Mechanism
Coded inside your mitochondrial DNA. It seems to manage metabolism and insulin sensitivity, and in animals it does a lot of what exercise does. Promising, but the human work is barely started.
Regulatory & Safety Status
Early research, not approved, and the human data is very limited. Treat the longevity claims as hopeful, not proven.
Research
Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model
Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study
MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia
MOTS-c metabolism and aging research
Latest MOTS-c research