Semaglutide
Approvedaka Ozempic, Wegovy, Rybelsus
Approved GLP-1 agonist. The drug that kicked off the whole weight-loss gold rush.
Mechanism
Copies the gut hormone GLP-1: slows your stomach down, kills appetite, and tightens up insulin response. Simple mechanism, huge results, which is why it's everywhere.
Regulatory & Safety Status
Approved: Ozempic and Rybelsus for diabetes, Wegovy for obesity. Get it prescribed. The compounded and grey-market stuff is where dosing accidents happen.
Research
Glucagon-like peptide-1 receptor agonists as a metabolic optimization strategy in surgical prehabilitation: a translational perspective
Semaglutide for the Silent Phenotype: A Translational Signal in Obesity-Driven HFpEF
Long-Term Safety and Renal Outcomes of Semaglutide in Non-Diabetic Obesity with Chronic Kidney Disease or Hypertension: A Systematic Review and Meta-Analysis
Repurposed Drugs and Cardiovascular Morbidity: A Cost-Effectiveness Analysis
STEP 1 weight management trial
Latest semaglutide research
In the News
FDA confirms semaglutide and tirzepatide off the drug shortage list
Supply is back, so the compounding pharmacies lose the shortage exemption. If you have been getting cheap compounded semaglutide, that tap is closing.
FDA warns consumers against unapproved and compounded GLP-1 products
The agency is flagging dosing mistakes and quality problems with compounded and counterfeit versions. Know your source, or skip it.
GLP-1 demand keeps obesity drugs the dominant pharma growth story
Capacity expansions and the next wave of triple-agonists keep obesity drugs the biggest story in pharma.